Butylphthalide

• Description :

  Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.

• Product Name Alternative :

  3-n-Butylphthalide; 3-Butylphthalide

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  P38 MAPK

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Butylphthalide.html

• Purity :

  99.98

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C1OC(CCCC)C2=C1C=CC=C2

• Molecular Formula :

  C12H14O2

• Molecular Weight :

  190.24

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl) . 2013;126 (18) :3405-10.|[2]Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9 (7) :719-26.|[3]Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12 (31) :5995-6004.|[4]Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36 (3) :224-33.|[5]Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W. Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (Engl) . 2019;132 (12) :1467-1477.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [6066-49-5]