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(Rac) -Tavapadon

CAT: 0804-HY-119486A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119486A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -Tavapadon ((Rac) -PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac) -Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM) . (Rac) -Tavapadon has antiparkinsonian activity[1].
CAS Number
1643462-64-9
Product Name Alternative
(Rac) -PF-06649751; (Rac) -CVL-751
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Arrestin; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-tavapadon.html
Purity
99.87
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O
Molecular Formula
C19H16F3N3O3
Molecular Weight
391.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10 (9) :4160-4182.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
D1 Receptor

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