WAY-181187

• Description :

  WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

• Product Name Alternative :

  SAX-187

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/way-181187.html

• Purity :

  98.83

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4

• Molecular Formula :

  C15H13ClN4O2S2

• Molecular Weight :

  380.87

• References & Citations :

  [1]Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33 (6) :1323-35.|[2]Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661 (1-3) :8-14.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 1

• Isoform :

  5-HT6 Receptor; MUC2

• CAS Number :

  [554403-49-5]