JAK-IN-36

JAK-IN-36

• UNSPSC Description: JAK-IN-36 (Compound 12e) is a potent and selective inhibitor of Janus Kinase 1 (JAK1) with a IC50 value of 2.2 nM. JAK-IN-36 can be used in the study of autoimmune diseases[1].
• Target Antigen: JAK
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/jak-in-36.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(CN2CCC(NC3=C4C(NC=C4)=NC=C3C5=CNN=C5)CC2)=CC=C1
• Molecular Weight: 406.91
• References & Citations: [1]Chen L, et al. Design, synthesis and evaluation of C-5 substituted pyrrolopyridine derivatives as potent Janus Kinase 1 inhibitors with excellent selectivity. Eur J Med Chem. 2024 Mar 5;267:116210.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported