Arotinolol-d5 (hydrochloride)

Arotinolol-d5 (hydrochloride)

• CAS Number: 2514848-16-7
• UNSPSC Description: Arotinolol-d5 (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker[1][2][3]. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases[1][2][3].
• Target Antigen: 5-HT Receptor; Adrenergic Receptor; Isotope-Labeled Compounds
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
• Field of Research: Cardiovascular Disease
• Smiles: O=C(C1=CC=C(S1)C2=CSC(SC([2H])(C([2H])(C([2H])(NC(C)(C)C)[2H])O)[2H])=N2)N.Cl
• Molecular Weight: 413.03
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats.PLoS One. 2014 Feb 12;9(2):e88722.|[3]Hiroshi TSUCHIHASHI, et al. Characteristics of 1251-lodocyanopindolol Binding to 8-Adrenergic and Serotonin-1B Receptors of Rat Brain: Selectivity of 19-Adrenergic Agents
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported