Arotinolol

• Description :

  Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker[1]. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites[2]. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases[1].

• CAS Number :

  [68377-92-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  5-HT Receptor; Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/arotinolol.html

• Purity :

  99.93

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C(C2=CSC(SCC(O)CNC(C)(C)C)=N2)S1)N

• Molecular Formula :

  C15H21N3O2S3

• Molecular Weight :

  371.54

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats.PLoS One. 2014 Feb 12;9 (2) :e88722.|[2]Hiroshi TSUCHIHASHI, et al. Characteristics of 1251-lodocyanopindolol Binding to 8-Adrenergic and Serotonin-1B Receptors of Rat Brain: Selectivity of 19-Adrenergic Agents

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; α-1 microglobulin