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Metopimazine

CAT: 0804-HY-116578-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116578-01Size:5 mg
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Description
Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3].
CAS Number
14008-44-7
Product Name Alternative
EXP999; RP9965
UNSPSC
12352005
Hazard Statement
H302
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metopimazine.html
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)C1CCN(CC1)CCCN2C3=C(SC4=CC=C(C=C24)S(=O)(C)=O)C=CC=C3
Molecular Formula
C22H27N3O3S2
Molecular Weight
445.60
Precautions
H302
References & Citations
[1]Victoire Roussel, et al. Estimating the excess of inappropriate prescriptions of anti-dopaminergic anti-emetics during acute gastroenteritis epidemics in France. Pharmacoepidemiol Drug Saf. 2013 Oct;22 (10) :1080-5.|[2]Mozgova O, et al. A new spectrophotometric method for the quantitative determination of Metopimazine based on the absorbance of its sulfoxide[J]. Chemical Papers, 2024, 78 (11) : 6585-6591.|[3]Jolliet P, et al. Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier. Pharmacol Res. 2007 Jul;56 (1) :11-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor

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