CORM-3

• UNSPSC Description:

  CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].

• Target Antigen:

  NF-κB; NOD-like Receptor (NLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/corm-3.html

• Purity:

  97.0

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O

• Molecular Weight:

  294.61

• References & Citations:

  [1]Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.|[2]Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963.|[3]Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  475473-26-8