L-Ascorbic acid

• Description:

  L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

• Product Name Alternative:

  L-Ascorbate; Vitamin C

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/L-Ascorbic-acid.html

• Purity:

  99.99

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

• Smiles:

  OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O

• Molecular Formula:

  C6H8O6

• Molecular Weight:

  176.12

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35.|[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82.|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5 (1) :2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  RT, protect from light

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Microbial Metabolite; T-type calcium channel

• Citation 01:

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• CAS Number:

  [50-81-7]