APX-115 (free base)

APX-115 (free base)

• Product Name Alternative: Ewha-18278 (free base); Isuzinaxib (free base)
• CAS Number: 1270084-92-8
• UNSPSC Description: APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
• Target Antigen: NADPH Oxidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Endocrinology; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/apx-115-freebase.html
• Purity: 98.11
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
• Molecular Weight: 279.34
• References & Citations: [1]Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.|[2]Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 2