Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2

• UNSPSC Description:

  Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*105 M-1s-1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*105 M-1s-1) and MMP9 (0.33*105 M-1s-1)[1].

• Target Antigen:

  MMP

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/mca-pro-leu-gly-leu-glu-glu-ala-dap-dnp-nh2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(N)=O)CNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)=O)=O)=O)CC(C3=CC=C(OC)C=C3O4)=CC4=O

• Molecular Weight:

  1195.19

• References & Citations:

  [1]Sarah Bregant, et al. Detection of matrix metalloproteinase active forms in complex proteomes: evaluation of affinity versus photoaffinity capture. J Proteome Res. 2009 May;8(5):2484-94.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  891198-38-2