DOV-216,303 (Free Base)

DOV-216,303 (Free Base)

• CAS Number: 66504-40-3
• UNSPSC Description: DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].
• Target Antigen: Dopamine Transporter; Serotonin Transporter
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/DOV-216,303_Free_Base.html
• Purity: 98.77
• Solubility: DMSO : ≥ 125 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
• Smiles: ClC1=C(Cl)C=C(C=C1)C12CC1CNC2
• Molecular Weight: 228.122
• References & Citations: [1]Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41.|[2]Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported