Brophenexin (free base)
CAT:
804-HY-139192A-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Brophenexin (free base)
- CAS Number: 1353979-43-7
- UNSPSC Description: Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
- Target Antigen: ERK; iGluR; TRP Channel
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/nmdar-trpm4-in-2-free-base.html
- Smiles: NCCN(CC1=CC=CC(Br)=C1)CC
- Molecular Weight: 257.18
- References & Citations: [1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.
- Shipping Conditions: Room Temperature