PDK4-IN-1

PDK4-IN-1

• CAS Number: 2310262-10-1
• UNSPSC Description: PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1].
• Target Antigen: Apoptosis; PDHK
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Field of Research: Cancer; Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pdk4-in-1.html
• Smiles: O=C1C2=C(C=CC=C2)C(C3=CC=CC(C4=CN(C5CCNCC5)N=C4)=C13)=O
• Molecular Weight: 357.41
• References & Citations: [1]Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588.
• Shipping Conditions: Room Temperature