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Flocoumafen

CAT: 0804-HY-111186-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111186-01Size:5 mg
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Description
Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects[1][2][3].
CAS Number
90035-08-8
Product Name Alternative
WL 108366
UNSPSC
12352005
Hazard Statement
H300+H310+H330, H360, H372, H410
Target
Glucocorticoid Receptor; MMP; VKOR
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/flocoumafen.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C2CC(C3=CC=C(OCC4=CC=C(C(F)(F)F)C=C4)C=C3)CC5=C2C=CC=C5)=C(O)C6=CC=CC=C6O1
Molecular Formula
C33H25F3O4
Molecular Weight
542.54
Precautions
H300+H310+H330, H360, H372, H410
References & Citations
[1]Nadia Coronado-Posada, et al. In Silico Analysis to Identify Molecular Targets for Chemicals of Concern: The Case Study of Flocoumafen, an Anticoagulant Pesticide. Environ Toxicol Chem. 2021 Jul;40 (7) :2034-2043.|[2]Sébastien Lefebvre, et al. Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences.|[3]Huckle KR, et al. Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration. Xenobiotica. 1988 Dec;18 (12) :1465-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-9

Alternative Products

CatalogName
90035-08-8Flocoumafen
450106-01Flocoumafen-d4

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