Recombinant Human CD30 Ligand/TNFSF8 Protein(His Tag)

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Recombinant Human CD30 Ligand/TNFSF8 Protein(His Tag)

CAT:

763-PDMH100341-01

Size:

100 µg

Price:

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For price, please contact [email protected].

Recombinant Human CD30 Ligand/TNFSF8 Protein(His Tag)

Background: CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals throμgh CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been sμggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.
Abbreviation: CD30 Ligand/TNFSF8
Synonyms: PSOR, CD antigen CD, Tumor necrosis factor ligand superfamily member, TNFSF, S100A, TNFSF8, CD153, CD30L, CD30LG, TNLG3A, CD antigen CD153, CD30 ligand, CD30-L, sCD30 Ligand, soluble CD30 Ligand, Tumor necrosis factor ligand superfamily member 8, S100A7, PSOR1, S100A7C, TNFSF8
UniProt: P32971
Accession Number: P32971
Host: Mammalian
Origin Species: Human
Tag: C-His
Sequence: Val63-Asp234
Field of Research: Immunology
Purity: > 90% as determined by reducing SDS-PAGE.
Bioactivity: Not validated for activity
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Molecular Weight: 40 kDa
Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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