H-L-Lys(4-N3-Z)-OH (hydrochloride)

H-L-Lys(4-N3-Z)-OH (hydrochloride)

• CAS Number: 2084913-49-3
• UNSPSC Description: H-L-Lys(4-N3-Z)-OH hydrochloride is a click chemistry reagent containing an azide group. H-L-Lys(4-N3-Z)-OH hydrochloride contains a lysine-modified azide moiety and as a bioorthogonal ligation handle. H-L-Lys(4-N3-Z)-OH hydrochloride is an infrared probe and a photo-affinity reagent[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/h-l-lys-4-n3-z-oh-hydrochloride.html
• Solubility: Methanol : 5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC([C@@H](N)CCCCNC(OCC1=CC=C(C=C1)N=[N+]=[N-])=O)=O.Cl
• Molecular Weight: 357.79
• References & Citations: [1]Ge Y, et, al. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem Sci. 2016 Dec 1;7(12):7055-7060.|[2]Wesalo JS, et, al. Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation. Chembiochem. 2020 Jan 15;21(1-2):141-148.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported