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Ischemin (sodium)

CAT: 0804-HY-110315-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110315-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia) [1].
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ischemin-sodium.html
Purity
99.32
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
CC1=CC(/N=N/C2=C(C=C(C(S(=O)(O[Na])=O)=C2)C)C)=C(C=C1O)N
Molecular Formula
C15H16N3NaO4S
Molecular Weight
357.36
References & Citations
[1]Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18 (4) :531-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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