MODAG-001

• Description :

  MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].

• UNSPSC :

  12352005

• Target :

  Fluorescent Dye

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/modag-001.html

• Purity :

  98.55

• Solubility :

  DMSO : 25 mg/mL (ultrasonic) |Methanol : 4.9 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

• Smiles :

  CN(C)C1=CC=C(C2=NNC(C3=CC(Br)=NC=C3)=C2)C=C1

• Molecular Formula :

  C16H15BrN4

• Molecular Weight :

  343.22

• References & Citations :

  [1]Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23 (12) :6371. |[2]Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. |[3]Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2648041-72-7]