MODAG-001

• UNSPSC Description:

  MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].

• Target Antigen:

  Fluorescent Dye

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/modag-001.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)|Methanol : 4.9 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)

• Smiles:

  CN(C)C1=CC=C(C2=NNC(C3=CC(Br)=NC=C3)=C2)C=C1

• Molecular Weight:

  343.22

• References & Citations:

  [1]Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23(12):6371. |[2]Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. |[3]Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2648041-72-7