Sibiriline

CAT: 0804-HY-120600Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-120600Size:1 Each

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Description

Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis.[1].

CAS Number

1346526-26-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sibiriline.html

Smiles

OC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2

Molecular Formula

C13H10N2O

Molecular Weight

210.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Sibirilin e, a new small chemical inhibitor of Receptor - Interacting Protein Kinase 1 , prevents immune -dependent hepatitis

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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