(R) -ML375

CAT: 0804-HY-12567A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-12567A-01Size:5 mg

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Description

(R) -ML375 ((R) -VU0483253) is an enantiomer of ML375. (R) -ML375 is devoid of M5 mAChR activity (hM5, IC50>30 μM).

CAS Number

1488362-56-6

Product Name Alternative

(R) -VU0483253

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Isomer

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/r-ml375.html

Purity

98.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2[C@](N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C=C4)C5=C1C=CC=C5

Molecular Formula

C23H15ClF2N2O2

Molecular Weight

424.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Patrick R Gentry, et al. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S) -9b- (4-chlorophenyl) -1- (3,4-difluorobenzoyl) -2,3-dihydro-1H-imidazo[2,1-a]isoindol-5 (9bH) -one (ML375) . J Med Chem. 2013 Nov 27;56 (22) :9351-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
BA5514-5.1	ML375

(R) -ML375

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