Products for Research Use Only
RegisterLogin

Flezurafenibum

CAT: 0804-HY-159534-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-159534-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Flezurafenibum (Flezurafenib) is a rapidly accelerated fibrosarcoma (Raf) kinase inhibitor, with antineoplastic effect[1].
CAS Number
2760321-00-2
Product Name Alternative
Flezurafenib
UNSPSC
12352101
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flezurafenibum.html
Smiles
O=C(CC1)N=C(NC=C2)C1=C2OC3=CC=C(OC[C@H](C4=NC=C(C5=CC=C(C=C5)F)N4)C6)C6=C3
Molecular Formula
C26H21FN4O3
Molecular Weight
456.47
References & Citations
[1]Flezurafenibum (Flezurafenib) . WHO Drug Information, Vol. 37, No. 4, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Flezurafenib

Flezurafenib is a small molecule drug. The usage of the INN stem '-rafenib' in the name indicates that Flezurafenib is a Raf (rapidly accelerated fibrosarcoma) kinase inhibitor. Flezurafenib has a monoisotopic molecular weight of 456.16 Da.

CAS Number2760321-00-2
PubChem CID162772363
IUPAC Name5-[[(3S)-3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
Molecular FormulaC26H21FN4O3
Molecular Weight456.5
XLogP3.6
Topological Polar Surface Area89.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count34
Formal Charge0
Complexity720
SMILES
C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC[C@@H](C4)C5=NC=C(N5)C6=CC=C(C=C6)F
InChI
InChI=1S/C26H21FN4O3/c27-18-3-1-15(2-4-18)21-13-29-25(30-21)17-11-16-12-19(5-7-22(16)33-14-17)34-23-9-10-28-26-20(23)6-8-24(32)31-26/h1-5,7,9-10,12-13,17H,6,8,11,14H2,(H,29,30)(H,28,31,32)/t17-/m1/s1
InChIKey
TWJSMWXWCWQPRO-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of Flezurafenib
CAS: 2760321-00-2
CID: 162772363
Formula: C26H21FN4O3
MW: 456.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.5
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass456.15976871
Monoisotopic Mass456.15976871
Topological Polar Surface Area89.1 Ų
Heavy Atom Count34
Formal Charge0
Complexity720
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T89252-01Flezurafenibum

Popular Products