2,2,5,7,8-Pentamethyl-6-Chromanol
CAT:
804-HY-111024-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
2,2,5,7,8-Pentamethyl-6-Chromanol
- CAS Number: 950-99-2
- UNSPSC Description: 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].
- Target Antigen: Androgen Receptor
- Type: Reference compound
- Related Pathways: Vitamin D Related/Nuclear Receptor
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/2-2-5-7-8-pentamethyl-6-chromanol.html
- Purity: 99.30
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: OC1=C(C)C(C)=C2C(CCC(C)(C)O2)=C1C
- Molecular Weight: 220.312
- References & Citations: [1]Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 2