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6-O-Methacrylate

CAT: 0804-HY-N8521-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8521-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC50 of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity[1][2].
CAS Number
950685-51-5
UNSPSC
12352005
Target
Parasite; TMV
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/6-o-methacrylate.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]([C@](O)(CC[C@H]2OC(C)=O)C)([H])[C@@H]([C@]3([H])[C@](OC(C3=C)=O)([H])[C@H]1OC(C)=O)OC(C(C)=C)=O
Molecular Formula
C23H30O9
Molecular Weight
450.48
References & Citations
[1]That QT, et, al. Wedelolides A and B: novel sesquiterpene delta-lactones, (9R) -eudesman-9,12-olides, from Wedelia trilobata. J Org Chem. 2007 Sep 14;72 (19) :7102-5.|[2]Li Y, et, al. Eudesmanolides from Wedelia trilobata (L.) Hitchc. as potential inducers of plant systemic acquired resistance. J Agric Food Chem. 2013 Apr 24;61 (16) :3884-90.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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