(S,R,S)-AHPC-PEG6-C4-Cl

(S,R,S)-AHPC-PEG6-C4-Cl

• CAS Number: 1835705-59-3
• UNSPSC Description: (S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_9.html
• Purity: 96.24
• Solubility: DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
• Molecular Weight: 827.47
• References & Citations: [1]Tovell H, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019 May 17;14(5):882-892.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported