C-DIM12

• Description :

  C-DIM12 is a potent, orally active Nurr1 modulator. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

• Product Name Alternative :

  DIM-C-pPhCl

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Nuclear Hormone Receptor 4A/NR4A

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/C-DIM12.html

• Purity :

  98.01

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

• Molecular Formula :

  C23H17ClN2

• Molecular Weight :

  356.85

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]De Miranda BR, et al. The Nurr1 Activator 1,1-Bis (3'-Indolyl) -1- (p-Chlorophenyl) Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87 (6) :1021-34. doi: 10.1124/mol.114.095398. Epub 2015 Apr 9.|[2]Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.|[3]Zarei M, et al. Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Res Commun. 2021;1 (2) :65-78.|[4]Sean L. Hammond, et al. The Nurr1 Ligand,1,1-bis (3′-Indolyl) -1- (p-Chlorophenyl) Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018 Jun; 365 (3) : 636–651.|[5]Keita Kinoshita, et al. A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice. Sci Rep. 2022; 12: 11009.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Nurr1/NR4A2

• CAS Number :

  [178946-89-9]