PKM2-IN-6

PKM2-IN-6

• CAS Number: 771467-00-6
• UNSPSC Description: PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer[1].
• Target Antigen: Apoptosis; Pyruvate Kinase
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pkm2-in-6.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: COC1=CC=CC=C1NC2=NC(C3=CN=C4C=CC=CN43)=CS2
• Molecular Weight: 322.38
• References & Citations: [1]Das R, et al. Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer. J Med Chem. 2024 Feb 26.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported