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UNC10142

CAT: 0804-HY-159989-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-159989-01Size:5 mg
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Description
UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC50 value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells[1].
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc10142.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OCCCN2CCCCC2)C=C(N=C(N3CCCCCCCC3)N=C4N(C)C5CCN(C(C)=O)CC5)C4=C1
Molecular Formula
C33H52N6O3
Molecular Weight
580.80
References & Citations
[1]Johnson RL, et al. Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer. J Med Chem. 2024 Nov 28;67 (22) :20056-20075.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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