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Lumasiran

CAT: 0804-HY-132588-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132588-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) [1][2].
CAS Number
1834610-13-7
Product Name Alternative
ALN-G01
UNSPSC
12352208
Target
Glycolate Oxidase; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lumasiran.html
Purity
98.77
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Lumasiran]
Molecular Formula
C530H712F10N173O320P43S6
Molecular Weight
16339.00
References & Citations
[1]Scott LJ, et al. Lumasiran: First Approval. Drugs. 2021;81 (2) :277-282.|[2]Garrelfs SF, et al. Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1. N Engl J Med. 2021;384 (13) :1216-1226.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched

Alternative Products

CatalogName
BA4979-1Lumasiran
MBS5799784Lumasiran sodium

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