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Tryptanthrin (Standard)

CAT: 0804-HY-N6607R-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6607R-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].
CAS Number
13220-57-0
UNSPSC
12352005
Target
COX; Interleukin Related; Leukotriene Receptor; NF-κB; NO Synthase; Reference Standards; TNF Receptor
Type
Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tryptanthrin-standard.html
Purity
98.77
Smiles
O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O
Molecular Formula
C15H8N2O2
Molecular Weight
248.24
References & Citations
[1]Zeng Q, et, al. Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. Acta Pharm. 2021 Jun 1;71 (2) :245-266.|[2]Pergola C, et, al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. Br J Pharmacol. 2012 Feb;165 (3) :765-76.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

Chemical Information

Tryptanthrin

Tryptanthrine is an organonitrogen heterocyclic compound, an organic heterotetracyclic compound and an alkaloid antibiotic.

CAS Number13220-57-0
PubChem CID73549
IUPAC Nameindolo[2,1-b]quinazoline-6,12-dione
Molecular FormulaC15H8N2O2
Molecular Weight248.24
XLogP2.1
Topological Polar Surface Area49.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count19
Formal Charge0
Complexity471
SMILES
C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2
InChI
InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H
InChIKey
VQQVWGVXDIPORV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tryptanthrin
CAS: 13220-57-0
CID: 73549
Formula: C15H8N2O2
MW: 248.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight248.24
XLogP32.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass248.058577502
Monoisotopic Mass248.058577502
Topological Polar Surface Area49.7 Ų
Heavy Atom Count19
Formal Charge0
Complexity471
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
TBW00934Tryptanthrin

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