Tryptanthrin

• Description:

  Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  COX; Interleukin Related; Leukotriene Receptor; NF-κB; NO Synthase; TNF Receptor

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tryptanthrin.html

• Purity:

  99.89

• Solubility:

  DMSO : 7.14 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O

• Molecular Formula:

  C15H8N2O2

• Molecular Weight:

  248.24

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zeng Q, et, al. Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. Acta Pharm. 2021 Jun 1;71 (2) :245-266.|[2]Pergola C, et, al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. Br J Pharmacol. 2012 Feb;165 (3) :765-76.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  IL-10; IL-12; IL-2; IL-6; nNOS; TNFRSF5/CD40

• CAS Number:

  [13220-57-0]