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L-Glutamic γ-monohydroxamate

CAT: 0804-HY-137874-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137874-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].
CAS Number
1955-67-5
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Peptides
Related Pathways
Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l-glutamic-γ-monohydroxamate.html
Purity
99.66
Solubility
H2O : 83.33 mg/mL (ultrasonic)
Smiles
N[C@H](C(O)=O)CCC(NO)=O
Molecular Formula
C5H10N2O4
Molecular Weight
162.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45 (4) :737-43.|[2]Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282 (6) :L1192-7.|[3]Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274 (37) :26617-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported

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