L-Glutamic acid

L-Glutamic acid

• CAS Number: 56-86-0
• UNSPSC Description: L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors[1][2][3][4][5].
• Target Antigen: Apoptosis; Endogenous Metabolite; Ferroptosis; iGluR
• Type: Natural Products
• Related Pathways: Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/_S_-Glutamic_acid.html
• Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 6.25 mg/mL (ultrasonic)
• Smiles: OC(CC[C@H](N)C(O)=O)=O
• Molecular Weight: 147.13
• References & Citations: [1] Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149.|[2]Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.|[3]Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132.|[4]Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30.|[5]Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163.Amino Acids. 2024 Sep 18;56(1):56.|J Transl Med. 2024 Feb 18;22(1):178.|Nature. 2024 Dec 18.|Neurochem Int. 2023 Jul 24;105587.|Redox Biol. 2024 Mar 4:71:103112.|Res Sq. 2024 Jun 03.|Res Sq. 2024 May 20.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched