L-Glutamic acid

• Description:

  L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA) . L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors[1][2][3][4][5].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Endogenous Metabolite; Ferroptosis; iGluR

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_S_-Glutamic_acid.html

• Concentration:

  10mM

• Purity:

  99.93

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 6.25 mg/mL (ultrasonic)

• Smiles:

  OC(CC[C@H](N)C(O)=O)=O

• Molecular Formula:

  C5H9NO4

• Molecular Weight:

  147.13

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1] Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149.|[2]Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6 (1) :73-7.|[3]Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27 (33) :42124-42132.|[4]Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217 (1-2) :26-30.|[5]Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  AMPA Receptor; Human Endogenous Metabolite; Microbial Metabolite

• Citation 01:

  Adv Sci (Weinh) . 2024 Dec 16:e2411479.|Adv Sci (Weinh) . 2025 Oct 5:e11194.|Amino Acids. 2024 Sep 18;56 (1) :56.|Cancer Immunol Immunother. 2025 Jun 7;74 (8) :240.|J Inflamm Res. 2025 Jan 27:18:1235-1254.|J Transl Med. 2024 Feb 18;22 (1) :178.|Nature. 2025 Jul;643 (8070) :192-200.|Neurochem Int. 2023 Oct:169:105587.|Neuropharmacology. 2025 Jun 15:271:110405.|Redox Biol. 2024 May:71:103112.|Res Sq. 2024 Jun 03.|Res Sq. 2024 May 20.

• CAS Number:

  [56-86-0]