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Thaspine (acetate)

CAT: 0804-HY-122481Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122481Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri[1].
CAS Number
74578-01-1
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Cytochrome P450; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thaspine-acetate.html
Smiles
O=C1C2=CC=C(OC)C(O3)=C2C4=C(C3=O)C(CCN(C)C)=CC(OC)=C4O1.CC(O)=O
Molecular Formula
C22H23NO8
Molecular Weight
429.42
References & Citations
[1]Fayad W, et al. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One. 2009 Oct 2;4 (10) :e7238.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bak; Bax; Topo I; Topo II

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