Products for Research Use Only
RegisterLogin

Pyripyropene A

CAT: 0804-HY-117832-01Size: 250 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-117832-01Size:250 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pyripyropene A is an orally active, potent and selective sterol O-acyltransferase 2 (SOAT2) /acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC50 of 0.07 μM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo[1][2][3][4].
CAS Number
147444-03-9
Product Name Alternative
3M-852A
UNSPSC
12352005
Hazard Statement
H302
Target
Acyltransferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pyripyropene-a.html
Purity
99.37
Solubility
10 mM in DMSO
Smiles
O=C1OC(C2=CC=CN=C2)=CC3=C1[C@H](O)[C@@]4([H])[C@]([C@@H](OC(C)=O)C[C@@]5([H])[C@](C)(COC(C)=O)[C@@H](OC(C)=O)CC[C@@]54C)(C)O3
Molecular Formula
C31H37NO10
Molecular Weight
583.63
Precautions
H302
References & Citations
[1]Hayashi A, et al. Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. Biol Pharm Bull. 2009 Jul;32 (7) :1261-5.|[2]Ohshiro T, et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31 (5) :1108-15.|[3]Lee KR , et al. Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies. Biomed Chromatogr. 2019 Feb;33 (2) :e4388.|[4]Ohtawa M, et al. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. ChemMedChem. 2018 Mar 6;13 (5) :411-421.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS5767410Pyripyropene A
MBS651362-01Pyripyropene A ((+)-Pyripyropene A, PPPA, FO 1289A)
GTR19255324-01Pyripyropene B
045185-01Pyripyropene A ((+) -Pyripyropene A, PPPA, FO 1289A)

Popular Products