Phox-I2

• Description:

  Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H335

• Target:

  NADPH Oxidase; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/phox-i2.html

• Purity:

  99.44

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=[N+]([O-])C1=CC(C2NC3=C(C4C2CC=C4)C=C(C=C3)[N+]([O-])=O)=CC=C1

• Molecular Formula:

  C18H15N3O4

• Molecular Weight:

  337.33

• Precautions:

  H302, H315, H335

• References & Citations:

  [1]Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67 (phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19 (2) :228-42.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [353495-22-4]