CRM1 rabbit pAb

CAT: 0855-ES20269-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES20269-01Size:50 µL

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Background

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES) -dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Description

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015],

UniProt

O14980

Swiss Prot

O14980

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human CRM1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Other Product Names

Exportin-1 (Exp1; Chromosome region maintenance 1 protein homolog)

Gene ID (Human)

7514

UniProtKB · O14980

Exportin-1

XPO1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O14980
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: XPO1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Exp1
EC number: —
Processing: —
Secondary accessions: A6NL14, A8K1K5, D6W5E2, Q63HP8, Q68CP3, Q99433

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionmRNA transportProtein transportTransport

Domain

Repeat

Molecular function

RNA-binding

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