Articaine (Standard)

• UNSPSC Description:

  Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway[1][2][3].

• Target Antigen:

  NF-κB; NOD-like Receptor (NLR); Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Membrane Transporter/Ion Channel;NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/articaine-standard.html

• Smiles:

  O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O

• Molecular Weight:

  284.37

• References & Citations:

  [1]Yapp KE, et al. Articaine: a review of the literature. Br Dent J. 2011 Apr 9;210(7):323-9.|[2]Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554.|[3]Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local Reg Anesth. 2012;5:23-33.

• Shipping Conditions:

  Room temperature

• CAS Number:

  23964-58-1