Products for Research Use Only
RegisterLogin

Articaine

CAT: 0804-HY-B0516A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0516A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) [1][2][3].
CAS Number
23964-58-1
Product Name Alternative
Hoe-045 (free base)
UNSPSC
12352005
Hazard Statement
H302
Target
NF-κB; NOD-like Receptor (NLR) ; Sodium Channel
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/articaine.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O
Molecular Formula
C13H20N2O3S
Molecular Weight
284.37
Precautions
P264-P270-P330-P501
References & Citations
[1]Wang GK, et al. State-dependent block of Na+ channels by articaine via the local anesthetic receptor. J Membr Biol. 2009 May;229 (1) :1-9.|[2]Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34 (10) :e22554.|[3]Rodrigues da Silva GH, et al. Articaine in functional NLC show improved anesthesia and anti-inflammatory activity in zebrafish. Sci Rep. 2020 Nov 12;10 (1) :19733.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NLRP3

Alternative Products

CatalogName
162683Articaine
441793-01Articaine Hydrochloride
sc-358046Articaine HCl
51-237Articaine Allergen

Popular Products