Protirelin (acetate)

• UNSPSC Description:

  Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

• Target Antigen:

  Thyroid Hormone Receptor

• Type:

  Peptides

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Protirelin-Acetate.html

• Purity:

  99.98

• Solubility:

  DMSO : 233.33 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CC3)NC3=O)=O)=O)CCC1.[1.5 CH3COOH]

• Molecular Weight:

  452.46

• References & Citations:

  [1]Van Sinay E, et al. Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074.|[2]Noda Y, et al. Hyperthermia induced by thyrotropin-releasing hormone (TRH, Protirelin) in the rat. Kurume Med J. 1979;26(2):107-12.Nat Immunol. 2024 Mar 18.|Obesity. 2024 Aug;32(8):1483-1493.|Cell Rep. 2024 Nov 9;43(11):114962.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  120876-23-5