Protirelin

• Description :

  Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

• Product Name Alternative :

  Thyrotropin-releasing-hormone; TRH

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; Thyroid Hormone Receptor

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Protirelin.html

• Purity :

  99.98

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CC3)NC3=O)=O)=O)CCC1

• Molecular Formula :

  C16H22N6O4

• Molecular Weight :

  362.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Van Sinay E, et al. Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2017 May 16;114 (20) :E4065-E4074.|[2]Noda Y, et al. Hyperthermia induced by thyrotropin-releasing hormone (TRH, Protirelin) in the rat. Kurume Med J. 1979;26 (2) :107-12.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  Launched

• Citation 01 :

  Cell Rep. 2024 Nov 9;43 (11) :114962.|Nat Immunol. 2024 Apr;25 (4) :659-670.|Obesity. 2024 Aug;32 (8) :1483-1493.

• CAS Number :

  [24305-27-9]