N6-Methyladenosine (Standard)

N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G (m6A) C (70%) or A (m6A) C (30%) . N6-methyladenosine (m6A) -containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits[2].

1867-73-8

6-Methyladenosine (Standard) ; N-Methyladenosine (Standard)

12352005

Endogenous Metabolite; Influenza Virus; Reference Standards

Reference Standards

Anti-infection; Metabolic Enzyme/Protease; Others

COVID-19-anti-virus

Infection

https://www.medchemexpress.com/n6-methyladenosine-standard.html

99.65

O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C3=C(N=C2)C(NC)=NC=N3

C11H15N5O4

281.27

[1]Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505 (7481) :117-20.|[2]Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21 (8) :1511-8.|[3]Dang W, et al. N6-Methyladenosine and Viral Infection. Front Microbiol. 2019 Mar 5;10:417.

Blue Ice

4°C, sealed storage, away from light and moisture