Fenhexamid

• Description:

  Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) [1].

• Product Name Alternative:

  KBR 2738

• UNSPSC:

  12352005

• Hazard Statement:

  H411

• Target:

  Estrogen Receptor/ERR; Fungal; PI3K

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/fenhexamid.html

• Concentration:

  10mM

• Purity:

  99.60

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=C(C(Cl)=C1Cl)O)C2(CCCCC2)C

• Molecular Formula:

  C14H17Cl2NO2

• Molecular Weight:

  302.20

• Precautions:

  H411

• References & Citations:

  [1]Debieu D, et al. The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) . Pest Manag Sci. 2001 Nov;57 (11) :1060-7.|[2]Go RE, et al., Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. Toxicol Appl Pharmacol. 2015 Nov 15;289 (1) :48-57.|[3]Medjakovic S, et al., Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor. Environ Toxicol. 2014 Oct;29 (10) :1201-16.|[4]Go RE, et al., A fungicide, fenhexamid, is involved in the migration and angiogenesis in breast cancer cells expressing estrogen receptors. Life Sci. 2022 Sep 15;305:120754.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [126833-17-8]