Lucerastat

CAT: 0804-HY-106392-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-106392-02Size:10 mM - 1 mL

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Description

Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS) . Lucerastat has the potential for Fabry disease study[1][2].

CAS Number

141206-42-0

Product Name Alternative

NB-DGJ; N- (n-Butyl) deoxygalactonojirimycin

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lucerastat.html

Purity

98.0

Solubility

DMSO : 22 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 24 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O

Molecular Formula

C10H21NO4

Molecular Weight

219.28

Precautions

H315, H319

References & Citations

[1]Sanne J van der Veen, et al. Developments in the Treatment of Fabry Disease. J Inherit Metab Dis. 2020 Feb 21.|[2]R.W.D. Welford, et al. Lucerastat, an Iminosugar for Substrate Reduction Therapy in Fabry Disease: Preclinical Evidence.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Chemical Information

Lucerastat

Lucerastat is under investigation in clinical trial NCT03425539 (Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease).

CAS Number	141206-42-0
PubChem CID	501391
IUPAC Name	(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular Formula	C10H21NO4
Molecular Weight	219.28
XLogP	-0.6
Topological Polar Surface Area	84.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	15
Formal Charge	0
Complexity	190

SMILES

CCCCN1C[C@@H]([C@H]([C@H]([C@H]1CO)O)O)O

InChI

InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9+,10-/m1/s1

InChIKey

UQRORFVVSGFNRO-XFWSIPNHSA-N

Chemical Structure

2D Structure

CAS: 141206-42-0

CID: 501391

Formula: C10H21NO4

MW: 219.28

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	219.28
XLogP3	-0.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	219.14705815
Monoisotopic Mass	219.14705815
Topological Polar Surface Area	84.2 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	190
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
319731	Lucerastat
AR-M04672-01	Migalastat Impurity 1 (Lucerastat)

Lucerastat

Chemical Information

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