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Toladryl

CAT: 0804-HY-138110-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138110-01Size:5 mg
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Description
Toladryl is a derivative of Diphenhydramine , capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].
CAS Number
19804-27-4
Product Name Alternative
4-Methyldiphenhydramine
UNSPSC
12352005
Hazard Statement
H302
Target
Endogenous Metabolite; Histamine Receptor; iGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/toladryl.html
Purity
97.23
Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C)C=C2
Molecular Formula
C18H23NO
Molecular Weight
269.38
Precautions
H302
References & Citations
[1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β- (P-methylbenzhydryloxy) -ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21 (4) : 353-370.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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