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4-Quinolinol

CAT: 0804-HY-59208-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-59208-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2].
CAS Number
611-36-9
Product Name Alternative
Kynurine
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-quinolinol.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=NC2=CC=CC=C12
Molecular Formula
C9H7NO
Molecular Weight
145.16
Precautions
H315, H319, H335
References & Citations
[1]Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8. |[2]Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174. |[3]Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478 (7368) :197-203.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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