DIF-3
CAT:
804-HY-145669-03
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DIF-3
- CAS Number: 113411-17-9
- UNSPSC Description: DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].
- Target Antigen: CDK; GSK-3
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dif-3.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(CCCCC)C1=C(C=C(C(Cl)=C1O)OC)O
- Molecular Weight: 272.72
- References & Citations: [1]Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported