DIF-3

CAT: 0931-T60485-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T60485-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

113411-17-9

Target

GSK-3, Wnt/beta-catenin, CDK

Related Pathways

PI3K/Akt/mTOR signaling, Stem Cells, Cytoskeletal Signaling, Cell Cycle/Checkpoint

Purity

0.9957

Bioactivity

DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].

Smiles

CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O

Molecular Formula

C13H17ClO4

Molecular Weight

272.72

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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BA3786-25	DIF-3
MBS7013772-01	Recombinant Protein dif-1 (dif-1)
sc-221541A	DIF-1
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5-04181	Fmoc-Phe(3,4-DiF)-OH
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