Products for Research Use Only
RegisterLogin

DPQ (hydrochloride)

CAT: 0804-HY-W424851Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W424851Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].
CAS Number
84050-22-6
Product Name Alternative
6,7-Dimethoxy-2- (1-piperazinyl) -4-quinazolinamine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dpq-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C=C(OC)C(OC)=CC2=NC(N3CCNCC3)=N1.[H]Cl
Molecular Formula
C14H20ClN5O2
Molecular Weight
325.79
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Meli E, et al. Differential role of poly (ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25 (1) :172-180.|[2]Wang G, et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response. PLoS One. 2013 Nov 21;8 (11) :e79757.|[3]Wang J, et al. Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis. Mol Med Rep. 2015 Mar;11 (3) :1768-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1

Related Products

CatalogName
HY-114869-01DPQ
HY-B0500BAlverine (hydrochloride)
HY-N14912β-Prumycin hydrochloride
HY-N0300A-01Tetrahydropalmatine (hydrochloride)
HY-172541LN6023 (hydrochloride)
HY-172070-01Metaescaline (hydrochloride)
HY-170052-01α-Isopropylaminohexanophenone (hydrochloride)
HY-168824-01Cypenamine (hydrochloride)
HY-161794A-01SP3N (hydrochloride)
HY-157255α-Dimethylaminopentiophenone (hydrochloride)

Alternative Products

CatalogName
300563Ligustrazine Hydrochloride (Chuanxiongzine hydrochloride)
D3190-91GDeoxynojirimycin Hydrochloride (DNJ Hydrochloride)
OR1043462-01Hydrochloride
MBS6103001-01O-Cyclopropylmethyl-hydroxylamine, Hydrochloride (Cyclopropylmethoxyamine, Hydrochloride, Cyclopropylmethoxylamine, Hydrochloride)
C7050-01Cysteamine hydrochloride; 2-AminoeThanethiol Hydrochloride; 2-Aminoethane-1-Thiol Hydrochloride; Mercaptamine Hydrochloride
P9050-45Propargylamine, Hydrochloride (2-Propynylamine, Hydrochloride)
46264200Thiamine hydrochloride (Vitamin B1 hydrochloride)
MBS6076243-01N-Butyldeoxynojirimycin, Hydrochloride (Miglustat, Hydrochloride)
A13041-100Istaroxime hydrochloride (PST2744 hydrochloride) 100mg
A13041-2Istaroxime hydrochloride (PST2744 hydrochloride) 2mg

Popular Products