Idarubicin (hydrochloride)

Idarubicin (hydrochloride)

• CAS Number: 57852-57-0
• UNSPSC Description: Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
• Target Antigen: Antibiotic; Autophagy; Bacterial; c-Myc; DNA/RNA Synthesis; Fungal; Topoisomerase
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/Idarubicin-hydrochloride.html
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[C@H](C[C@@](C(C)=O)(O)CC4=C3O)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5N.Cl
• Molecular Weight: 533.95
• References & Citations: [1]Orlandi P, et al. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. J Chemother. 2005 Dec;17(6):663-7.|[2]Robert J. Clinical pharmacokinetics of idarubicin. Clin Pharmacokinet. 1993 Apr;24(4):275-88.|[3]Siegsmund MJ, et al. Enhanced in vitro cytotoxicity of idarubicin compared to epirubicin and doxorubicin in rat prostate carcinoma cells. Eur Urol. 1997;31(3):365-70.|[4]Gewirtz DA, et al. Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line. Cancer Chemother Pharmacol. 1998;41(5):361-|[5]Kinnunen U, et al. Idarubicin inhibits the growth of bacteria and yeasts in an automated blood culture system. Eur J Clin Microbiol Infect Dis. 2009 Mar;28(3):301-3.Anal Chem. 2022 Oct 4;94(39):13623-13630.|bioRxiv. 2023 Jan 13.|Cancer Lett. 2019 Oct 1;461:31-43. |Exp Cell Res. 2020 Aug 1;393(1):112054.|iScience. 2024 Jun 07.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|J Virol. 2019 May 15;93(11):e02230-18. |Nat Cell Biol. 2024 Jul 22.|Nat Commun. 2020 Apr 14;11(1):1792.|Nucleic Acids Res. 2018 Apr 20;46(7):3284-3297.|University of Paris. 2022 Sep 19.|Viruses. 2020 Jun 10;12(6):628.|Mol Carcinog. 2023 Jul 26.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched